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Agua = Saneamiento=20 y Salud (AAS)
Calida= d del=20 agua potable
Ag= ua de=20 balnearios
= Recursos=20 h=C3=ADdricos
Monitoreo=20 del AAS
De= sarrollo=20 del AAS y la higiene
E= nfermedades=20 relacionadas con el agua
Uso de=20 aguas residuales
Residuos = de centros=20 de salud
T= emas=20 emergentes
A= spectos=20 econ=C3=B3micos
Publicaciones

Productos farmac=C3=A9uticos en el agua potable =

Resumen de las principales conclusiones y recomendaciones = incluidas en=20 el informe t=C3=A9cnico de la OMS sobre productos farmac=C3=A9uticos en = el agua potable y=20 de las contribuciones de otros expertos que efectuaron la revisi=C3=B3n = entre=20 hom=C3=B3logos.

Antecedentes y =C3=A1mbito

Los productos farmac=C3=A9uticos son sustancias qu=C3=ADmicas = sint=C3=A9ticas o=20 naturales que se pueden encontrar en medicamentos recetados, de venta = libre y=20 veterinarios. Estos productos contienen ingredientes activos = dise=C3=B1ados para=20 provocar efectos farmacol=C3=B3gicos y beneficiar significativamente a = la sociedad.=20

Los f=C3=A1rmacos se pueden introducir en las fuentes de agua a = trav=C3=A9s de=20 aguas residuales que transportan excretas de personas y pacientes que = los hayan=20 utilizado; por eliminaci=C3=B3n inapropiada de medicamentos (por = ejemplo,=20 arroj=C3=A1ndolos por el inodoro); y por medio de residuos l=C3=ADquidos = agr=C3=ADcolas,=20 incluido el esti=C3=A9rcol del ganado. Estos productos se han convertido = en una=20 cuesti=C3=B3n de creciente preocupaci=C3=B3n para el p=C3=BAblico, = debido a que podr=C3=ADan llegar=20 a las fuentes de agua potable.

Presencia de productos qu=C3=ADmicos en el = agua potable

El uso generalizado de los productos farmac=C3=A9uticos (tanto = recetados=20 como de venta libre) ha dado lugar a una descarga continua de esos = productos y=20 sus metabolitos en las aguas residuales. Adem=C3=A1s, los productos = farmac=C3=A9uticos=20 llegan a las fuentes de agua a trav=C3=A9s de los efluentes de = instalaciones de=20 fabricaci=C3=B3n o producci=C3=B3n insuficientemente controladas, = principalmente las=20 relacionadas con los medicamentos gen=C3=A9ricos.

Gracias a las mejoras en la sensibilidad de los m=C3=A9todos = anal=C3=ADticos para=20 la medici=C3=B3n de esos productos qu=C3=ADmicos en concentraciones muy = bajas, algunos=20 estudios revelaron concentraciones de trazas de productos = farmac=C3=A9uticos en aguas=20 residuales, fuentes de agua y aguas potables. Por lo general, las=20 concentraciones en aguas superficiales, subterr=C3=A1neas y parcialmente = tratadas=20 eran inferiores a 0.1 =C2=B5g/l (or 100 ng/l), mientras que en el agua = tratada eran=20 inferiores a 0.05 =C2=B5g/l (or 50 ng/l). Estas investigaciones sugieren = que los=20 productos farmac=C3=A9uticos est=C3=A1n presentes, aunque en = concentraciones m=C3=ADnimas, en=20 muchas fuentes de agua que reciben efluentes de aguas = residuales.

La presencia de los productos farmac=C3=A9uticos = espec=C3=ADficos en una fuente=20 de agua puede variar de un lugar a otro en funci=C3=B3n del tipo de = productos=20 farmac=C3=A9uticos y la magnitud de la descarga en las masas de agua. = Los factores=20 determinantes son los productos farmac=C3=A9uticos recetados, utilizados = o fabricados=20 en la zona, as=C3=AD como el tama=C3=B1o de la poblaci=C3=B3n en la = cuenca de captaci=C3=B3n. La=20 presencia y la concentraci=C3=B3n de productos farmac=C3=A9uticos en las = fuentes de agua=20 receptoras, que son la v=C3=ADa principal hacia el agua potable, = dependen de la=20 diluci=C3=B3n, la atenuaci=C3=B3n natural y el tipo de tratamiento de = aguas residuales=20 aplicado.

Evaluaci=C3=B3n de riesgos de = incorporaci=C3=B3n de productos=20 farmac=C3=A9uticos en el agua potable

Actualmente existen pocos programas de seguimiento = sistem=C3=A1tico y=20 estudios completos sobre la exposici=C3=B3n humana a productos = farmac=C3=A9uticos=20 presentes en el agua potable. Por lo tanto, el limitado n=C3=BAmero de = datos=20 disponibles sobre la presencia de diversos grupos de productos = farmac=C3=A9uticos=20 utilizados en la actualidad, as=C3=AD como de sus metabolitos activos, = representa un=20 desaf=C3=ADo clave para evaluar el riesgo potencial para la salud humana = derivado de=20 la exposici=C3=B3n a concentraciones muy bajas de productos = farmac=C3=A9uticos en el agua=20 potable. Sin embargo, en el =C3=A1mbito de la literatura cient=C3=ADfica = se han publicado=20 diversos m=C3=A9todos de detecci=C3=B3n y priorizaci=C3=B3n de productos = farmac=C3=A9uticos, que=20 permiten evaluar los riesgos para la salud humana derivados de la = exposici=C3=B3n a=20 esos productos a trav=C3=A9s del agua potable.

Por lo general esos m=C3=A9todos se rigen por el principio de = la "dosis=20 terap=C3=A9utica m=C3=ADnima" (tambi=C3=A9n llamada "dosis m=C3=ADnima = efectiva cl=C3=ADnicamente") o la=20 ingesta diaria admisible, junto con factores de seguridad o de = incertidumbre=20 relativos a los diferentes grupos de productos farmac=C3=A9uticos, a fin = de deducir=20 un margen de seguridad o de exposici=C3=B3n entre el peor caso de = exposici=C3=B3n=20 observado o previsto, y la dosis terap=C3=A9utica m=C3=ADnima o la = ingesta diaria=20 admisible.

Las observaciones actuales sugieren que es muy poco probable = que la=20 exposici=C3=B3n a niveles muy bajos de productos farmac=C3=A9uticos = presentes en el agua=20 potable pueda suponer riesgos adversos apreciables para la salud humana, = ya que=20 las concentraciones de esos productos detectadas en el agua potable=20 (generalmente en magnitudes de nanogramos por litro) son varias = =C3=B3rdenes de=20 magnitud (por lo general m=C3=A1s de 1.000 veces y con frecuencia mucho = m=C3=A1s a=C3=BAn)=20 inferiores a la dosis terap=C3=A9utica m=C3=ADnima.

Medidas de control y gesti=C3=B3n de = riesgos

Las concentraciones de la gran mayor=C3=ADa de productos = farmac=C3=A9uticos en el=20 agua se pueden reducir mediante procesos naturales (por ejemplo, = adsorci=C3=B3n sobre=20 los sedimentos, fotodegradaci=C3=B3n solar y degradaci=C3=B3n = biol=C3=B3gica) o durante los=20 procesos posteriores de tratamiento de agua potable y aguas residuales. = A pesar=20 de sus propiedades farmacol=C3=B3gicas =C3=BAnicas, la respuesta de los = productos=20 farmac=C3=A9uticos al tratamiento no difiere de la de otros productos = qu=C3=ADmicos=20 org=C3=A1nicos, y las tasas de eliminaci=C3=B3n dependen de sus = propiedades=20 f=C3=ADsico-qu=C3=ADmicas y de la tecnolog=C3=ADa utilizada en el = tratamiento.

Los procesos convencionales de tratamiento de agua, por = ejemplo, la=20 cloraci=C3=B3n, pueden eliminar aproximadamente el 50% de estos = compuestos, mientras=20 que los procesos de tratamiento m=C3=A1s avanzados, tales como la = ozonizaci=C3=B3n, la=20 oxidaci=C3=B3n avanzada, el carb=C3=B3n activado, la nanofiltraci=C3=B3n = y la =C3=B3smosis inversa=20 pueden lograr mayores tasas de eliminaci=C3=B3n; la =C3=B3smosis = inversa, por ejemplo,=20 puede eliminar m=C3=A1s del 99% de las grandes mol=C3=A9culas de = productos=20 farmac=C3=A9uticos.

Como cualquier intervenci=C3=B3n de salud p=C3=BAblica, el = financiamiento de toda=20 medida para mejorar la seguridad del agua procede de recursos limitados = que se=20 deben asignar cuidadosamente, teniendo en cuenta sus efectos = ben=C3=A9ficos. Sin=20 embargo, la introducci=C3=B3n de sistemas adicionales especializados y = costosos para=20 el tratamiento de agua potable, en particular para reducir las = concentraciones=20 de trazas de productos farmac=C3=A9uticos, no se considera necesaria en = este momento,=20 dado que el beneficio para la salud humana ser=C3=ADa = limitado.

El enfoque m=C3=A1s adecuado para minimizar la presencia de = productos=20 farmac=C3=A9uticos en el agua potable y reducir la exposici=C3=B3n = humana consiste en=20 prevenir o reducir su paso al medio acu=C3=A1tico, en la medida que sea=20 razonablemente viable. Esto se puede lograr mediante una = combinaci=C3=B3n de medidas=20 preventivas tales como el suministro de mejor informaci=C3=B3n al = p=C3=BAblico sobre el=20 uso y la eliminaci=C3=B3n racional de los medicamentos y productos = farmac=C3=A9uticos (por=20 ejemplo, evitar arrojar por el inodoro medicamentos no utilizados); la=20 capacitaci=C3=B3n de los prescriptores y la ejecuci=C3=B3n = sistem=C3=A1tica de programas de=20 recuperaci=C3=B3n de medicamentos.

Sin embargo, en consonancia con el plan para la seguridad del = agua=20 basado en el principio de control de contaminantes en la fuente, = ser=C3=ADa apropiado=20 tratar de mejorar los m=C3=A9todos de tratamiento de aguas residuales = con el fin de=20 suprimir de la principal v=C3=ADa de entrada en el medio acu=C3=A1tico = los productos=20 farmac=C3=A9uticos y otros preocupantes contaminantes = potenciales.

Seguimiento de la presencia de productos = farmac=C3=A9uticos=20 en el agua

En vista de la falta de disposiciones normativas, el = seguimiento=20 regular de la presencia de productos farmac=C3=A9uticos en las fuentes = de agua y el=20 agua potable a escala nacional no ser=C3=ADa conveniente, excepto en = casos en los que=20 las circunstancias locales sugirieran la posibilidad de concentraciones = elevadas=20 (por ejemplo, f=C3=A1bricas con descargas de efluentes en el curso = superior de una=20 fuente de agua potable).

En esas circunstancias se puede realizar un seguimiento de=20 investigaci=C3=B3n, por ejemplo, de las aguas superficiales y = subterr=C3=A1neas, as=C3=AD como=20 de los efluentes de aguas residuales, a fin de evaluar los niveles de = presencia=20 y exposici=C3=B3n posibles; en caso necesario, los valores detectados se = pueden=20 elaborar junto con una evaluaci=C3=B3n de los riesgos potenciales para = la salud=20 humana derivados de la exposici=C3=B3n a los productos = farmac=C3=A9uticos por medio del=20 agua potable.

Sobre la base de los resultados de esa evaluaci=C3=B3n de = riesgos se podr=C3=ADan=20 examinar posibles medidas de control, como parte de un plan de seguridad = del=20 agua. Entre las dificultades pr=C3=A1cticas asociadas con la = ejecuci=C3=B3n de programas=20 de seguimiento de los productos farmac=C3=A9uticos se incluyen la falta = de protocolos=20 estandarizados de muestreo y an=C3=A1lisis, los elevados costos y la = limitada=20 disponibilidad de los instrumentos de an=C3=A1lisis necesarios para = medir la diversa=20 gama de productos farmac=C3=A9uticos que podr=C3=ADan estar presentes. =

Las encuestas de investigaci=C3=B3n deber=C3=ADan adaptarse a = las circunstancias=20 locales, teniendo en cuenta los procesos existentes para el tratamiento = de aguas=20 residuales y de agua, y los productos farmac=C3=A9uticos (y sus = metabolitos) que se=20 com=C3=BAnmente prescritos, utilizados o fabricados en la zona de = captaci=C3=B3n en=20 cuesti=C3=B3n. Tales estudios deber=C3=ADan realizarse con las adecuadas = garant=C3=ADas y=20 rigurosas comprobaciones de calidad, y planificarse con miras a = determinar si el=20 agua potable plantea un riesgo significativo.

Falta de conocimientos

Si bien las actuales evaluaciones de riesgos indican que es muy = improbable que las baj=C3=ADsimas concentraciones de productos = farmac=C3=A9uticos=20 presentes en el agua potable planteen un riesgo considerable para la = salud=20 humana, existen lagunas de conocimientos. Entre ellas se incluyen la = falta de=20 evaluaci=C3=B3n de los riesgos para la salud humana asociados a la = exposici=C3=B3n=20 prolongada a bajas concentraciones de productos farmac=C3=A9uticos, y = los posibles=20 efectos combinados derivados de las mezclas de productos = farmac=C3=A9uticos.=20

Aunque los m=C3=A1rgenes de exposici=C3=B3n son sustanciales, = ser=C3=ADa conveniente=20 confirmar que esos m=C3=A1rgenes son adecuados para potenciales = subpoblaciones=20 sensibles, y caracterizar mejor los riesgos sanitarios, si los hubiere, = de las=20 exposiciones de bajo nivel a largo plazo. Adem=C3=A1s, la = investigaci=C3=B3n futura=20 deber=C3=ADa centrarse en el desarrollo de m=C3=A9todos o protocolos = para priorizar la=20 evaluaci=C3=B3n global de todos los riesgos derivados de productos = farmac=C3=A9uticos=20 relacionados con el agua potable.

Resumen

En la actualidad, el an=C3=A1lisis de los datos disponibles = indica que=20 existe un margen de seguridad considerable entre las baj=C3=ADsimas = concentraciones=20 de productos farmac=C3=A9uticos que se consumir=C3=ADan con el agua = potable y las dosis=20 terap=C3=A9uticas m=C3=ADnimas, lo que sugiere un riesgo exiguo para la = salud humana. De=20 esta conclusi=C3=B3n se desprende que, actualmente, en el marco de las = Gu=C3=ADas de la=20 OMS para la calidad del agua potable no es necesario desarrollar valores = de=20 referencia formales basados en la salud, en relaci=C3=B3n con los = productos=20 farmac=C3=A9uticos.

Las preocupaciones concernientes a los productos = farmac=C3=A9uticos en el=20 agua potable no deber=C3=ADan desviar la atenci=C3=B3n de los = proveedores de agua y de las=20 instancias normativas, de otras prioridades relativas al agua potable y = la=20 salud, especialmente los riesgos microbianos que entra=C3=B1an las = bacterias, los=20 virus y los protozoos pat=C3=B3genos, as=C3=AD como otros riesgos = qu=C3=ADmicos tales como el=20 ars=C3=A9nico de origen natural y los excesivos niveles de = fluoruro.

Consciente de que los productos farmac=C3=A9uticos en el agua = potable=20 constituyen un problema incipiente, la OMS seguir=C3=A1 examinando las = pruebas=20 cient=C3=ADficas pertinentes y, en caso necesario, actualizar=C3=A1 la = orientaci=C3=B3n=20 proporcionada en la presente hoja informativa.

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Enlaces

Gu=C3=ADas=20 de la OMS para la calidad del agua potable
Productos=20 farmac=C3=A9uticos en el agua potable - en ingl=C3=A9s
Informe t=C3=A9cnico
Manual=20 para el desarrollo de planes de seguridad del agua: metodologia = pormenorizada=20 de gestion de riesgos para proveedores de agua de consumo. =

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$(document).keydown(keyHandler);=0A= modal.content.css({width: 'auto', height: 'auto'});=0A= modal.contentWrapper.css({width: 'auto', height: 'auto'});=0A= }=0A= }=0A= =0A= // Show the modal (ie: the background and then the loading if needed or = the content directly)=0A= function showModal() {=0A= debug('showModal');=0A= if (!modal.ready) {=0A= initModal();=0A= modal.anim =3D true;=0A= currentSettings.showBackground(modal, currentSettings, endBackground);=0A= } else {=0A= modal.anim =3D true;=0A= modal.transition =3D true;=0A= currentSettings.showTransition(modal, currentSettings, = function(){endHideContent();modal.anim=3Dfalse;showContentOrLoading();});=0A= }=0A= }=0A= =0A= // Used for the escape key or the arrow in the gallery type=0A= function keyHandler(e) {=0A= if (e.keyCode =3D=3D 27) {=0A= if (!currentSettings.modal)=0A= removeModal();=0A= } else if (currentSettings.type =3D=3D 'gallery' && modal.ready && = modal.dataReady && !modal.anim && !modal.transition) {=0A= if 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(jFrom.attr('title'))=0A= currentSettings.title =3D jFrom.attr('title');=0A= =0A= var imgType =3D imageType(url, from);=0A= if (imgType)=0A= return imgType;=0A= =0A= if (from.target && from.target.toLowerCase() =3D=3D '_blank' || = (from.hostname && from.hostname.replace(/:\d*$/,'') !=3D = window.location.hostname.replace(/:\d*$/,''))) {=0A= return 'iframe';=0A= } else if (from.nodeName.toLowerCase() =3D=3D 'form') {=0A= setCurrentSettings(extractUrlSel(url));=0A= if (jFrom.attr('enctype') =3D=3D 'multipart/form-data')=0A= return 'formData';=0A= return 'form';=0A= }=0A= } else {=0A= url =3D currentSettings.url;=0A= if (!currentSettings.content)=0A= currentSettings.from =3D true;=0A= =0A= if (!url)=0A= return null;=0A= =0A= var reg1 =3D new RegExp("^http://", "g");=0A= if (url.match(reg1))=0A= return 'iframe';=0A= }=0A= =0A= var imgType =3D imageType(url, from);=0A= if (imgType)=0A= return imgType;=0A= =0A= var swf =3D new RegExp('[^\.]\.(swf)\s*$', 'i');=0A= if (swf.test(url))=0A= return 'swf';=0A= =0A= var tmp =3D extractUrlSel(url);=0A= setCurrentSettings(tmp);=0A= =0A= if (!tmp.url)=0A= return tmp.selector;=0A= }=0A= =0A= function imageType(url, from) {=0A= var image =3D new RegExp(currentSettings.regexImg, 'i');=0A= if (image.test(url)) {=0A= if (from && from.rel)=0A= return 'gallery';=0A= else=0A= return 'image';=0A= }=0A= }=0A= =0A= function extractUrlSel(url) {=0A= var ret =3D {=0A= url: null,=0A= selector: null=0A= };=0A= =0A= if (url) {=0A= var hash =3D getHash(url);=0A= var hashLoc =3D getHash(window.location.href);=0A= var curLoc =3D window.location.href.substring(0, = window.location.href.length - hashLoc.length);=0A= var req =3D url.substring(0, url.length - hash.length);=0A= =0A= if (req =3D=3D curLoc) {=0A= ret.selector =3D hash;=0A= } else {=0A= ret.url =3D req;=0A= ret.selector =3D hash;=0A= }=0A= }=0A= return ret;=0A= }=0A= =0A= // Called when the content cannot be loaded or tiemout reached=0A= function loadingError() {=0A= debug('loadingError');=0A= =0A= modal.error =3D true;=0A= =0A= if (!modal.ready)=0A= return;=0A= =0A= if ($.isFunction(currentSettings.handleError))=0A= currentSettings.handleError(modal, currentSettings);=0A= =0A= modal.loading=0A= .addClass(currentSettings.errorClass)=0A= .html(currentSettings.contentError);=0A= $(currentSettings.closeSelector, modal.loading).click(removeModal);=0A= setMarginloading();=0A= modal.loading=0A= .css({=0A= marginTop: currentSettings.marginTopLoading+'px',=0A= marginLeft: currentSettings.marginLeftLoading+'px'=0A= });=0A= }=0A= =0A= // Put the content from modal.tmp to modal.content=0A= function fillContent() {=0A= debug('fillContent');=0A= if (!modal.tmp.html())=0A= return;=0A= =0A= modal.content.html(modal.tmp.contents());=0A= modal.tmp.empty();=0A= wrapContent();=0A= =0A= if ($.isFunction(currentSettings.endFillContent))=0A= currentSettings.endFillContent(modal, currentSettings);=0A= =0A= modal.content.append(modal.scripts);=0A= =0A= var currentSettingsNew =3D $.extend({}, currentSettings);=0A= if (resized.width)=0A= currentSettingsNew.width =3D null;=0A= if (resized.height)=0A= currentSettingsNew.height =3D null;=0A= $(currentSettings.closeSelector, = modal.contentWrapper).click(removeModal);=0A= $(currentSettings.openSelector, = modal.contentWrapper).nyroModal(currentSettingsNew);=0A= }=0A= =0A= // Wrap the content and update the modal size if needed=0A= function wrapContent() {=0A= debug('wrapContent');=0A= =0A= var wrap =3D $(currentSettings.wrap[currentSettings.type]);=0A= modal.content.append(wrap.children().remove());=0A= modal.contentWrapper.wrapInner(wrap);=0A= =0A= if (currentSettings.type =3D=3D 'gallery') {=0A= // Set the action for the next and prev button (or remove them)=0A= =0A= var linkPrev =3D getGalleryLink(-1);=0A= if (linkPrev) {=0A= $('.nyroModalPrev', modal.contentWrapper)=0A= .attr('href', linkPrev.attr('href'))=0A= .click(function(e) {=0A= e.preventDefault();=0A= linkPrev.nyroModalManual(currentSettings);=0A= return false;=0A= });=0A= } else {=0A= $('.nyroModalPrev', modal.contentWrapper).remove();=0A= }=0A= var linkNext =3D getGalleryLink(1);=0A= if (linkNext) {=0A= $('.nyroModalNext', modal.contentWrapper)=0A= .attr('href', linkNext.attr('href'))=0A= .click(function(e) {=0A= e.preventDefault();=0A= linkNext.nyroModalManual(currentSettings);=0A= return false;=0A= });=0A= } else {=0A= $('.nyroModalNext', modal.contentWrapper).remove();=0A= }=0A= }=0A= =0A= calculateSize();=0A= }=0A= =0A= function getGalleryLink(dir) {=0A= if (currentSettings.type =3D=3D 'gallery') {=0A= if (!currentSettings.ltr)=0A= dir *=3D -1;=0A= // next=0A= var gallery =3D $('[rel=3D"'+currentSettings.from.rel+'"]');=0A= var currentIndex =3D gallery.index(currentSettings.from);=0A= var index =3D currentIndex + dir;=0A= if (index >=3D 0 && index < gallery.length)=0A= return gallery.eq(index);=0A= }=0A= return false;=0A= }=0A= =0A= // Calculate the size for the contentWrapper=0A= function calculateSize(resizing) {=0A= debug('calculateSize');=0A= =0A= if (!modal.wrapper)=0A= modal.wrapper =3D modal.contentWrapper.children(':first');=0A= =0A= resized.width =3D false;=0A= resized.height =3D false;=0A= if (currentSettings.autoSizable && (!currentSettings.width || = !currentSettings.height)) {=0A= modal.contentWrapper.css({opacity: 0}).show();=0A= var tmp =3D {=0A= width: 'auto',=0A= height: 'auto'=0A= };=0A= if (currentSettings.width)=0A= tmp.width =3D currentSettings.width;=0A= if (currentSettings.height)=0A= tmp.height =3D currentSettings.height;=0A= modal.content.css(tmp);=0A= if (!currentSettings.width) {=0A= currentSettings.width =3D modal.content.width();=0A= resized.width =3D true;=0A= }=0A= if (!currentSettings.height) {=0A= currentSettings.height =3D modal.content.height();=0A= resized.height =3D true;=0A= }=0A= modal.contentWrapper.hide().css({opacity: 1});=0A= }=0A= =0A= currentSettings.width =3D Math.max(currentSettings.width, = currentSettings.minWidth);=0A= currentSettings.height =3D Math.max(currentSettings.height, = currentSettings.minHeight);=0A= =0A= var outerWrapper =3D getOuter(modal.contentWrapper);=0A= var outerWrapper2 =3D getOuter(modal.wrapper);=0A= var outerContent =3D getOuter(modal.content);=0A= =0A= var tmp =3D {=0A= content: {=0A= width: currentSettings.width,=0A= height: currentSettings.height=0A= },=0A= wrapper2: {=0A= width: currentSettings.width + outerContent.w.total,=0A= height: currentSettings.height + outerContent.h.total=0A= },=0A= wrapper: {=0A= width: currentSettings.width + outerContent.w.total + = outerWrapper2.w.total,=0A= height: currentSettings.height + outerContent.h.total + = outerWrapper2.h.total=0A= }=0A= };=0A= =0A= if (currentSettings.resizable) {=0A= var maxHeight =3D $(window).height()=0A= - currentSettings.padding*2=0A= - outerWrapper.h.border=0A= - (tmp.wrapper.height - currentSettings.height);=0A= var maxWidth =3D $(window).width()=0A= - currentSettings.padding*2=0A= - outerWrapper.w.border=0A= - (tmp.wrapper.width - currentSettings.width);=0A= =0A= if (tmp.content.height > maxHeight || tmp.content.width > maxWidth) {=0A= // We're gonna resize the modal as it will goes outside the view port=0A= if (currentSettings.type =3D=3D 'image' || currentSettings.type = =3D=3D 'gallery') {=0A= // An image is resized proportionnaly=0A= var diffW =3D tmp.content.width - currentSettings.imgWidth;=0A= var diffH =3D tmp.content.height - currentSettings.imgHeight;=0A= if (diffH < 0) diffH =3D 0;=0A= if (diffW < 0) diffW =3D 0;=0A= var calcH =3D maxHeight - diffH;=0A= var calcW =3D maxWidth - diffW;=0A= var ratio =3D Math.min(calcH/currentSettings.imgHeight, = calcW/currentSettings.imgWidth);=0A= =0A= calcH =3D Math.floor(currentSettings.imgHeight*ratio);=0A= calcW =3D Math.floor(currentSettings.imgWidth*ratio);=0A= $('img#nyroModalImg', modal.content).css({=0A= height: calcH+'px',=0A= width: calcW+'px'=0A= });=0A= tmp.content.height =3D calcH + diffH;=0A= tmp.content.width =3D calcW + diffW;=0A= } else {=0A= // For an HTML content, we simply decrease the size=0A= tmp.content.height =3D Math.min(tmp.content.height, maxHeight);=0A= tmp.content.width =3D Math.min(tmp.content.width, maxWidth);=0A= }=0A= tmp.wrapper2 =3D {=0A= width: tmp.content.width + outerContent.w.total,=0A= height: tmp.content.height + outerContent.h.total=0A= };=0A= tmp.wrapper =3D {=0A= width: tmp.content.width + outerContent.w.total + = outerWrapper2.w.total,=0A= height: tmp.content.height + outerContent.h.total + = outerWrapper2.h.total=0A= };=0A= }=0A= }=0A= =0A= modal.content.css($.extend({}, tmp.content, = currentSettings.css.content));=0A= modal.wrapper.css($.extend({}, tmp.wrapper2, = currentSettings.css.wrapper2));=0A= =0A= if (!resizing) {=0A= modal.contentWrapper.css($.extend({}, tmp.wrapper, = currentSettings.css.wrapper));=0A= if (currentSettings.type =3D=3D 'image' || currentSettings.type = =3D=3D 'gallery') {=0A= // Adding the title for the image=0A= var title =3D $('img', modal.content).attr('alt');=0A= $('img', modal.content).removeAttr('alt');=0A= if (title !=3D currentSettings.defaultImgAlt) {=0A= var divTitle =3D $('

'+title+'

');=0A= modal.content.append(divTitle);=0A= if (currentSettings.setWidthImgTitle) {=0A= var outerDivTitle =3D getOuter(divTitle);=0A= divTitle.css({width: (tmp.content.width + outerContent.w.padding - = outerDivTitle.w.total)+'px'});=0A= }=0A= }=0A= }=0A= =0A= if (!currentSettings.modal)=0A= modal.contentWrapper.prepend(currentSettings.closeButton);=0A= }=0A= =0A= if (currentSettings.title)=0A= modal.contentWrapper.prepend('

'+currentSettings.title+'

');=0A= =0A= tmp.wrapper.borderW =3D outerWrapper.w.border;=0A= tmp.wrapper.borderH =3D outerWrapper.h.border;=0A= =0A= setCurrentSettings(tmp.wrapper);=0A= setMargin();=0A= }=0A= =0A= function removeModal(e) {=0A= debug('removeModal');=0A= if (e)=0A= e.preventDefault();=0A= if (modal.full && modal.ready) {=0A= modal.ready =3D false;=0A= modal.anim =3D true;=0A= modal.closing =3D true;=0A= if (modal.loadingShown || modal.transition) {=0A= currentSettings.hideLoading(modal, currentSettings, function() {=0A= modal.loading.hide();=0A= modal.loadingShown =3D false;=0A= modal.transition =3D false;=0A= currentSettings.hideBackground(modal, currentSettings, endRemove);=0A= });=0A= } else {=0A= if (fixFF)=0A= modal.content.css({position: ''}); // Fix Issue #10, remove the = attribute=0A= modal.wrapper.css({overflow: 'hidden'}); // Used to fix a visual = issue when hiding=0A= modal.content.css({overflow: 'hidden'}); // Used to fix a visual = issue when hiding=0A= if ($.isFunction(currentSettings.beforeHideContent)) {=0A= currentSettings.beforeHideContent(modal, currentSettings, = function() {=0A= currentSettings.hideContent(modal, currentSettings, function() {=0A= endHideContent();=0A= currentSettings.hideBackground(modal, currentSettings, endRemove);=0A= });=0A= });=0A= } else {=0A= currentSettings.hideContent(modal, currentSettings, function() {=0A= endHideContent();=0A= currentSettings.hideBackground(modal, currentSettings, endRemove);=0A= });=0A= }=0A= }=0A= }=0A= if (e)=0A= return false;=0A= }=0A= =0A= function showContentOrLoading() {=0A= debug('showContentOrLoading');=0A= if (modal.ready && !modal.anim) {=0A= if (modal.dataReady) {=0A= if (modal.tmp.html()) {=0A= modal.anim =3D true;=0A= if (modal.transition) {=0A= fillContent();=0A= currentSettings.hideTransition(modal, currentSettings, function() {=0A= modal.loading.hide();=0A= modal.transition =3D false;=0A= modal.loadingShown =3D false;=0A= endShowContent();=0A= });=0A= } else {=0A= currentSettings.hideLoading(modal, currentSettings, function() {=0A= modal.loading.hide();=0A= modal.loadingShown =3D false;=0A= fillContent();=0A= setMarginloading();=0A= currentSettings.showContent(modal, $.extend({}, = currentSettings), endShowContent);=0A= });=0A= }=0A= }=0A= } else if (!modal.loadingShown && !modal.transition) {=0A= modal.anim =3D true;=0A= modal.loadingShown =3D true;=0A= if (modal.error)=0A= loadingError();=0A= else=0A= modal.loading.html(currentSettings.contentLoading);=0A= $(currentSettings.closeSelector, modal.loading).click(removeModal);=0A= setMarginloading();=0A= currentSettings.showLoading(modal, currentSettings, = function(){modal.anim=3Dfalse;showContentOrLoading();});=0A= }=0A= }=0A= }=0A= =0A= =0A= // -------------------------------------------------------=0A= // Private Data Loaded callback=0A= // -------------------------------------------------------=0A= =0A= function ajaxLoaded(data) {=0A= debug('AjaxLoaded: '+this.url);=0A= modal.tmp.html(currentSettings.selector=0A= = ?filterScripts($('

'+data+'

').find(currentSettings.selector).co= ntents())=0A= :filterScripts(data));=0A= if (modal.tmp.html()) {=0A= modal.dataReady =3D true;=0A= showContentOrLoading();=0A= } else=0A= loadingError();=0A= }=0A= =0A= function formDataLoaded() {=0A= debug('formDataLoaded');=0A= var jFrom =3D $(currentSettings.from);=0A= jFrom.attr('action', jFrom.attr('action')+currentSettings.selector);=0A= jFrom.attr('target', '');=0A= $('input[name=3D'+currentSettings.formIndicator+']', = currentSettings.from).remove();=0A= var iframe =3D modal.tmp.children('iframe');=0A= var iframeContent =3D = iframe.unbind('load').contents().find(currentSettings.selector || = 'body').not('script[src]');=0A= iframe.attr('src', 'about:blank'); // Used to stop the loading in FF=0A= modal.tmp.html(iframeContent.html());=0A= if (modal.tmp.html()) {=0A= modal.dataReady =3D true;=0A= showContentOrLoading();=0A= } else=0A= loadingError();=0A= }=0A= =0A= =0A= // -------------------------------------------------------=0A= // Private Animation callback=0A= // -------------------------------------------------------=0A= =0A= function endHideContent() {=0A= debug('endHideContent');=0A= modal.anim =3D false;=0A= if (contentEltLast) {=0A= contentEltLast.append(modal.content.contents());=0A= contentEltLast=3D null;=0A= } else if (contentElt) {=0A= contentElt.append(modal.content.contents());=0A= contentElt=3D null;=0A= }=0A= modal.content.empty();=0A= modal.contentWrapper=0A= .empty()=0A= .removeAttr('style');=0A= =0A= if (modal.closing || modal.transition)=0A= modal.contentWrapper.hide();=0A= =0A= modal.contentWrapper=0A= .css(currentSettings.css.wrapper)=0A= .append(modal.content);=0A= showContentOrLoading();=0A= }=0A= =0A= function endRemove() {=0A= debug('endRemove');=0A= $(document).unbind('keydown', keyHandler);=0A= modal.anim =3D false;=0A= modal.full.remove();=0A= modal.full =3D null;=0A= if (isIE6) {=0A= body.css({height: '', width: '', position: '', overflow: ''});=0A= $('html').css({overflow: ''});=0A= }=0A= if ($.isFunction(currentSettings.endRemove))=0A= currentSettings.endRemove(modal, currentSettings);=0A= }=0A= =0A= function endBackground() {=0A= debug('endBackground');=0A= modal.ready =3D true;=0A= modal.anim =3D false;=0A= showContentOrLoading();=0A= }=0A= =0A= function endShowContent() {=0A= debug('endShowContent');=0A= modal.anim =3D false;=0A= modal.contentWrapper.css({opacity: ''}); // for the close button in IE=0A= fixFF =3D $.browser.mozilla && parseFloat($.browser.version) < 1.9 && = currentSettings.type !=3D 'gallery' && currentSettings.type !=3D 'image';=0A= if (fixFF)=0A= modal.content.css({position: 'fixed'}); // Fix Issue #10=0A= if ($.isFunction(currentSettings.endShowContent))=0A= currentSettings.endShowContent(modal, currentSettings);=0A= if (resized.width)=0A= setCurrentSettings({width: null});=0A= if (resized.height)=0A= setCurrentSettings({height: null});=0A= }=0A= =0A= =0A= // -------------------------------------------------------=0A= // Utilities=0A= // -------------------------------------------------------=0A= =0A= // Get the selector from an url (as string)=0A= function getHash(url) {=0A= if (typeof url =3D=3D 'string') {=0A= var hashPos =3D url.indexOf('#');=0A= if (hashPos > -1)=0A= return url.substring(hashPos);=0A= }=0A= return '';=0A= }=0A= =0A= // Filter an html content to remove the script[src]=0A= function filterScripts(data) {=0A= // Removing the body, head and html tag=0A= if (typeof data =3D=3D 'string')=0A= data =3D data.replace(/<\/?(html|head|body)([^>]*)>/gi, '');=0A= var tmp =3D new Array();=0A= $.each($.clean({0:data}, this.ownerDocument), function() {=0A= if ($.nodeName(this, "script")) {=0A= if (!this.src || $(this).attr('rel') =3D=3D 'forceLoad')=0A= modal.scripts.push(this);=0A= } else=0A= tmp.push(this);=0A= });=0A= return tmp;=0A= }=0A= =0A= // Get the vertical and horizontal margin, padding and border dimension=0A= function getOuter(elm) {=0A= elm =3D elm.get(0);=0A= var ret =3D {=0A= h: {=0A= margin: getCurCSS(elm, 'marginTop') + getCurCSS(elm, 'marginBottom'),=0A= border: getCurCSS(elm, 'borderTopWidth') + getCurCSS(elm, = 'borderBottomWidth'),=0A= padding: getCurCSS(elm, 'paddingTop') + getCurCSS(elm, = 'paddingBottom')=0A= },=0A= w: {=0A= margin: getCurCSS(elm, 'marginLeft') + getCurCSS(elm, 'marginRight'),=0A= border: getCurCSS(elm, 'borderLeftWidth') + getCurCSS(elm, = 'borderRightWidth'),=0A= padding: getCurCSS(elm, 'paddingLeft') + getCurCSS(elm, = 'paddingRight')=0A= }=0A= };=0A= =0A= ret.h.outer =3D ret.h.margin + ret.h.border;=0A= ret.w.outer =3D ret.w.margin + ret.w.border;=0A= =0A= ret.h.inner =3D ret.h.padding + ret.h.border;=0A= ret.w.inner =3D ret.w.padding + ret.w.border;=0A= =0A= ret.h.total =3D ret.h.outer + ret.h.padding;=0A= ret.w.total =3D ret.w.outer + ret.w.padding;=0A= =0A= return ret;=0A= }=0A= =0A= function getCurCSS(elm, name) {=0A= var ret =3D parseInt($.curCSS(elm, name, true));=0A= if (isNaN(ret))=0A= ret =3D 0;=0A= return ret;=0A= }=0A= =0A= function isDoctypeStrict() {=0A= var doctype =3D '';=0A= if ($.browser.opera) {=0A= return true;=0A= } else if ($.browser.msie) {=0A= var re =3D /\s+(X?HTML)\s+([\d\.]+)\s*([^\/]+)*\//gi;=0A= var res =3D false;=0A= if($.browser.msie)=0A= res =3D document.all[0].nodeType =3D=3D 8 ? = re.test(document.all[0].nodeValue) : false;=0A= if (res)=0A= doctype =3D RegExp.$3;=0A= } else=0A= doctype =3D document.doctype.systemId;=0A= return doctype.toLowerCase().indexOf('strict') > -1=0A= }=0A= =0A= // Proxy Debug function=0A= function debug(msg) {=0A= if ($.fn.nyroModal.settings.debug || currentSettings && = currentSettings.debug)=0A= nyroModalDebug(msg, modal, currentSettings || {});=0A= }=0A= =0A= // -------------------------------------------------------=0A= // Default animation function=0A= // -------------------------------------------------------=0A= =0A= function showBackground(elts, settings, callback) {=0A= elts.bg.css({opacity:0}).fadeTo(500, 0.75, callback);=0A= }=0A= =0A= function hideBackground(elts, settings, callback) {=0A= elts.bg.fadeOut(300, callback);=0A= }=0A= =0A= function showLoading(elts, settings, callback) {=0A= elts.loading=0A= .css({=0A= marginTop: settings.marginTopLoading+'px',=0A= marginLeft: settings.marginLeftLoading+'px',=0A= opacity: 0=0A= })=0A= .show()=0A= .animate({=0A= opacity: 1=0A= }, {complete: callback, duration: 400});=0A= }=0A= =0A= function hideLoading(elts, settings, callback) {=0A= callback();=0A= }=0A= =0A= function showContent(elts, settings, callback) {=0A= elts.loading=0A= .css({=0A= marginTop: settings.marginTopLoading+'px',=0A= marginLeft: settings.marginLeftLoading+'px'=0A= })=0A= .show()=0A= .animate({=0A= width: settings.width+'px',=0A= height: settings.height+'px',=0A= marginTop: settings.marginTop+'px',=0A= marginLeft: settings.marginLeft+'px'=0A= }, {duration: 350, complete: function() {=0A= elts.contentWrapper=0A= .css({=0A= width: settings.width+'px',=0A= height: settings.height+'px',=0A= marginTop: 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